Sequence-Specific Photomodification of DNA by an Oligonucleotide-Phenanthrodihydrodioxin Conjugate
نویسندگان
چکیده
منابع مشابه
Sequence-specific photomodification of DNA by an oligonucleotide-phenanthrodihydrodioxin conjugate.
We introduce a new member of a family of photochemically active oligonucleotide conjugates. A Phenanthrodihydrodioxin (PDHD)-based agent was synthesized and covalently linked to a 5'-end of the 9-mer oligonucleotide via a hexamethylene linker. The conjugate hybridized to a complementary 30-nucleotide-long target and efficiently cleaved it in a sequence specific manner. Up to 67% of target was s...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 1998
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc970209a